UHS PGET Medicine & Allied MCQs by Subject: Anatomy, Pharmacology & Pathology

Sample UHS PGET Medicine & Allied MCQs from Anatomy, Pharmacology and Pathology — the three basic-science subjects that carry weight across every PGET specialty paper.

UHS PGET Medicine & Allied splits its question pool across more than two dozen basic-science and specialty subjects. Anatomy, Pharmacology and Pathology are three of the biggest by volume in HighYield's own Medicine & Allied bank, and because they sit in Paper I's shared basic-sciences syllabus, the same three subjects carry real weight in the Surgery and Obstetrics & Gynaecology banks too. Below is a sample from each.

Anatomy

1. The recurrent laryngeal nerve is a branch of which cranial nerve?

A) Glossopharyngeal nerve
B) Vagus nerve ✅
C) Hypoglossal nerve
D) Accessory nerve

The recurrent laryngeal nerve, a branch of the vagus, supplies every intrinsic laryngeal muscle except cricothyroid; the left loops under the aortic arch and the right under the subclavian artery, which is why it is at risk in thyroid and cardiothoracic surgery.

2. Which carpal bone is most commonly fractured, with a well-known risk of avascular necrosis?

A) Lunate
B) Triquetrum
C) Scaphoid ✅
D) Capitate

The scaphoid has a retrograde blood supply entering distally, so a fracture through its waist can cut off flow to the proximal fragment and cause avascular necrosis if missed.

Pharmacology

3. Methotrexate interferes with DNA synthesis mainly by inhibiting which enzyme?

A) Thymidylate synthase
B) Dihydrofolate reductase ✅
C) Ribonucleotide reductase
D) DNA topoisomerase II

Blocking dihydrofolate reductase stops the regeneration of tetrahydrofolate, starving rapidly dividing cells of the one-carbon units they need for purine and thymidylate synthesis; folinic acid (leucovorin) can rescue normal cells from toxicity.

4. Which antihypertensive class is avoided in pregnancy because of fetal renal toxicity?

A) Calcium channel blockers
B) Beta blockers
C) ACE inhibitors ✅
D) Thiazide diuretics

ACE inhibitors (and ARBs) reduce fetal renal perfusion and can cause oligohydramnios, renal failure and skull defects when used in the second and third trimesters.

Pathology

5. Psammoma bodies are a classic finding in which of the following?

A) Follicular carcinoma of the thyroid
B) Papillary carcinoma of the thyroid ✅
C) Medullary carcinoma of the thyroid
D) Anaplastic carcinoma of the thyroid

Psammoma bodies — concentric, calcified laminated structures — turn up in papillary thyroid carcinoma, serous cystadenocarcinoma of the ovary, meningioma and mesothelioma; they are not a feature of the other thyroid cancer subtypes.

6. Caseous necrosis is the classic tissue reaction seen in which condition?

A) Acute pancreatitis
B) Tuberculosis ✅
C) Myocardial infarction
D) Gout

Caseous necrosis combines features of coagulative and liquefactive necrosis, producing the soft, cheese-like material seen at the centre of tuberculous granulomas.

Why These Three Subjects Matter for Every PGET Paper

It's easy to put all your revision time into the specialty subject you're applying for and treat Anatomy, Pharmacology and Pathology as "already done" from undergrad. In HighYield's Medicine & Allied bank these three subjects together make up a large share of the basic-sciences pool, and the same pattern holds in the Surgery and Obstetrics & Gynaecology banks, so time spent here isn't wasted if you switch specialty.

HighYield's UHS PGET Medicine & Allied question bank covers every subject in both papers, each question explained. For a broader sample across cardiovascular, respiratory and endocrine topics, see our UHS PGET Medicine & Allied MCQs guide, or read the PGET exam pattern guide first.