FCPS IMM Infectious Diseases MCQs: High-Yield Practice Questions & Prep

Sample FCPS IMM Medicine infectious diseases MCQs on HIV, malaria, typhoid, diarrhoeal illness, STIs and tropical infections, with explanations.

Infectious diseases in IMM reflects what Pakistani physicians actually see: typhoid, malaria, dengue, HIV with its opportunistic infections, diarrhoeal disease and sexually transmitted infections. Below is a sample set with explanations.

Sample Infectious Diseases MCQs

1. A patient comes to you with diarrhoea; he tells you that duration of diarrhoea is now 6 weeks, he had bulky stools and history of travel. What is your diagnosis?

A) Giardiasis ✅
B) Shigellosis
C) Cholera
D) Amoebiasis

Why: Giardiasis causes prolonged, bulky, foul-smelling, greasy diarrhoea with bloating and flatulence after travel or drinking contaminated water. It is diagnosed by stool antigen or cysts and treated with metronidazole or tinidazole.

2. A patient with constipation, abdominal pain. He is having headache, nuchal rigidity, having fever of 102 but pulse 90. Diagnosis?

A) Dengue fever
B) Enteric fever ✅
C) Malaria
D) Measles

Why: Fever with relative bradycardia, constipation and headache is typical of typhoid fever, which can also produce meningism.

3. HIV patient develops white plaques over the lateral surface of tongue. Diagnosis?

A) HPV infection
B) Candidiasis
C) Hairy cell leukoplakia ✅
D) HSV infection

Why: Non-scrapable white corrugated plaques on the lateral tongue are oral hairy leukoplakia (EBV) in HIV, whereas Candida plaques scrape off.

4. Lymphoma patient with herpes infection, took acyclovir for 3 days, but no improvement, treatment for him now?

A) Acyclovir + lamivudine + amantadine
B) IV acyclovir
C) Acyclovir plus steroids
D) IV foscarnet ✅

Why: Failure of acyclovir in an immunocompromised patient suggests thymidine kinase-deficient resistant HSV, treated with foscarnet.

5. A patient returned from Sibi, treatment with chloroquine advised, but malaria didn't settle. Now primaquine given, cause:

A) Plasmodium ovale
B) Plasmodium malariae
C) Plasmodium vivax ✅
D) Plasmodium falciparum

Why: Primaquine kills the dormant liver hypnozoites of P. vivax and P. ovale, preventing relapse after chloroquine.

6. A middle-aged diabetic female develops proptosis with blackening of her face. Drug of choice?

A) Tetracycline
B) Methotrexate
C) Amphotericin ✅
D) Cyclophosphamide

Why: Proptosis with black necrotic facial tissue in a diabetic indicates rhinocerebral mucormycosis, treated with amphotericin B.

7. A 22-week pregnant female is diagnosed with toxoplasmosis. What is the treatment of choice?

A) Ciprofloxacin
B) Pyrimethamine
C) No treatment required
D) Spiramycin ✅

Why: Spiramycin is used in pregnancy to reduce vertical transmission of toxoplasmosis, since pyrimethamine is teratogenic.

8. Pregnant lady diagnosed with chlamydia infection is allergic to penicillin, next treatment option for her?

A) Doxycycline
B) Ciprofloxacin
C) Erythromycin ✅
D) Ofloxacin

Why: Erythromycin (or azithromycin) is used in pregnancy, because tetracyclines and fluoroquinolones are contraindicated.

How to Approach Infectious Diseases for IMM

Link each HIV opportunistic infection to the CD4 range at which it appears.
Know the classic diagnostic test and first-line drug for the endemic infections.
Match food-poisoning organisms to the time from meal to symptoms.

Browse every Infectious Diseases question on its own: Infectious Diseases MCQs.

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