NLE Hematology MCQs: Practice Questions With Explanations

Sample NLE MCQs from Hematology — a 69-question subject in HighYield's NLE bank without a dedicated practice post yet — covering anemia types, bleeding disorders and transfusion basics.

Hematology is a 69-question subject in HighYield's NLE (National Licensing Examination) question bank that doesn't yet have a dedicated practice post. Below is a sample set of Hematology MCQs covering anemia, bleeding disorders and transfusion basics.

Anemia

1. A patient has microcytic hypochromic anemia with a low serum ferritin. What is the most likely cause?

A) Iron deficiency anemia ✅
B) Anemia of chronic disease
C) Thalassemia trait
D) Sideroblastic anemia

2. A patient has macrocytic anemia with hypersegmented neutrophils on peripheral smear. What deficiency is most likely?

A) Iron
B) Vitamin B12 or folate ✅
C) Vitamin C
D) Vitamin K

3. A patient of African descent presents with a painful vaso-occlusive crisis and a peripheral smear showing sickle cells and target cells. What is the diagnosis?

A) Sickle cell anemia ✅
B) Hereditary spherocytosis
C) G6PD deficiency
D) Thalassemia major

Bleeding & Clotting Disorders

4. A patient has an isolated prolonged prothrombin time (PT) with a normal PTT. Which factor deficiency is classically responsible?

A) Factor VII ✅
B) Factor VIII
C) Factor IX
D) Factor XII

5. A patient has a prolonged bleeding time, normal platelet count, mucocutaneous bleeding and a family history of easy bruising. What is the most likely diagnosis?

A) Hemophilia A
B) Von Willebrand disease ✅
C) Vitamin K deficiency
D) Disseminated intravascular coagulation

6. Which clotting factor is deficient in Hemophilia A?

A) Factor VIII ✅
B) Factor IX
C) Factor XI
D) Von Willebrand factor

Transfusion Basics

7. Which blood group is considered the universal red cell donor?

A) A negative
B) O negative ✅
C) AB positive
D) O positive

8. Which blood group is considered the universal plasma donor?

A) O negative
B) AB ✅
C) A positive
D) B negative

Prepare with HighYield

HighYield's NLE question bank covers Hematology alongside Surgery, General Medicine, Paediatrics and every other subject tested in the National Licensing Examination, with every question explained. New to the exam structure? Start with our NLE Syllabus breakdown.