DHA Exam Oncology MCQs: Practice Questions With Answers

Sample DHA licensing exam MCQs from Oncology — a specialty area in HighYield's DHA bank without a dedicated practice post yet — covering tumor markers, paraneoplastic syndromes, and hereditary cancer genes, each with the correct answer explained.

Oncology is one of the specialty areas in HighYield's DHA question bank without a dedicated practice post, and it's tested through a recognisable set of high-yield facts rather than obscure detail — tumor markers, classic paraneoplastic pairings, and hereditary cancer syndromes come up repeatedly. Below is a sample set grouped by theme.

Tumor Markers

1. Which tumor marker is most associated with monitoring colorectal cancer?

A) CA-125
B) Carcinoembryonic antigen (CEA) ✅
C) Alpha-fetoprotein (AFP)
D) CA 19-9

2. Elevated CA-125 is most classically associated with:

A) Prostate cancer
B) Ovarian cancer ✅
C) Pancreatic cancer
D) Testicular cancer

3. Alpha-fetoprotein (AFP) is a tumor marker most associated with:

A) Hepatocellular carcinoma and germ cell tumors ✅
B) Breast cancer
C) Lymphoma
D) Renal cell carcinoma

Paraneoplastic Syndromes

4. Small cell lung cancer is classically associated with which paraneoplastic syndrome?

A) Hypercalcemia via PTHrP
B) Syndrome of inappropriate ADH secretion (SIADH) ✅
C) Polycythemia
D) Carcinoid syndrome

5. Hypercalcemia of malignancy via PTHrP secretion is most classically associated with:

A) Squamous cell carcinoma of the lung ✅
B) Small cell lung cancer
C) Adenocarcinoma of the pancreas
D) Multiple myeloma only

Hereditary Cancer Genes

6. Mutations in BRCA1 and BRCA2 most significantly raise lifetime risk of which two cancers?

A) Colorectal and gastric cancer
B) Breast and ovarian cancer ✅
C) Lung and bladder cancer
D) Thyroid and renal cancer

Why Oncology Deserves Dedicated Revision

Oncology questions on the DHA exam tend to reward exactly this kind of pattern recognition — a fixed set of marker-to-cancer and syndrome-to-cancer associations that repeat far more than they vary, making focused revision unusually efficient.

HighYield's DHA question bank covers Oncology alongside Gastroenterology, Cardiology and every other discipline tested in the DHA licensing exam, with every question explained. For the full picture of what the DHA exam covers, see our DHA Exam Guide. Start with 50 free questions, no sign-in required.